Molecules | Free Full-Text | Weinreb Amides as Directing

A decarboxylative approach for regioselective Sep 05, 2016 Direct C H Amidation of Benzoic Acids to Introduce meta R. N. Prasad Tulichala, Mallepalli Shankar, K. C. Kumara Swamy, Palladium-Catalyzed Decarboxylative ortho -Amidation of Indole-3-carboxylic Acids with Isothiocyanates Using Carboxyl as a Deciduous Directing Group , The Journal of Organic Chemistry, 10.1021/acs.joc.8b00042, 83, 8, (4375-4383), (2018). Rh(III)-catalyzed decarboxylative ortho-heteroarylation of Apr 03, 2015

To increase the rate of esterase-catalyzed bioconversion of prodrug 1a, thus decreasing its biliary clearance, the oxymethyl-modified prodrug 1, in which an aldehyde equivalent is inserted between the phenolic group of the promoiety and the carboxylic acid group of the peptide, was synthesized from Benzofuran-2-carboxylic acid 16 via a nine

Carboxylic Acids as Traceless Directing Groups for Formal meta-Selective Direct Arylation Josep Cornella, Marika Righi, Igor Larrosa * Angew. Chem. Int. Ed. 2011, 40, 9429-32. 20. A Novel Mode of Reactivity for Gold(I): the decarboxylative aureation of (hetero)aromatic carboxylic acids Josep Cornella, Martin Rosillo-Lopez, Igor Larrosa * Adv

obstacle consists of installing directing groups into substrates to direct the functionalisation towards the desired C–H bond, leaving behind the directing group in the molecule. Alternatively, carboxylic acids have been employed as traceless directing groups that are easily removed after carboxylic acid-directed

Benzofuran-2-carboxylic acid | CAS:496-41-3 For Research To increase the rate of esterase-catalyzed bioconversion of prodrug 1a, thus decreasing its biliary clearance, the oxymethyl-modified prodrug 1, in which an aldehyde equivalent is inserted between the phenolic group of the promoiety and the carboxylic acid group of the peptide, was synthesized from Benzofuran-2-carboxylic acid 16 via a nine Cobalt-Catalyzed Selective Synthesis of Isoquinolines molecules (Scheme 1). Traceless directing groups, the removal of which does not require additional steps, would be more attractive alternatives. However, the functional groups that can be employed as the traceless directing groups remain relatively rare.3 Recently, carboxylic acid,4 N-oxide,5 silicon-tethered,6 Dichloromethane as a methylene synthon for regioselective